mifepristone will enhance the level or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
A monoamine oxidase inhibitor (MAOI), which can be a medicine usually useful for depression or Parkinson’s condition
Medications that have phase therapy linked to Each and every prescription. This restriction generally demands that selected requirements be fulfilled prior to approval for that prescription.
It's got antioxidant Attributes that could reduce the existence of harmful free radicals from the Mind tissue, which makes it an effective neuroprotectant.[twenty five]
Modafinil appeared to create a concentration-relevant suppression of CYP2C9 action, as a result suggesting prospective for CYP2C9 inhibition; warning if prescription drugs which have a narrow therapeutic index
iloperidone raises levels of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Iloperidone is actually a time-dependent CYP3A inhibitor and should produce increased plasma levels of prescription drugs predominantly eliminated by CYP3A4.
Restrictions of Use In OSA, modafinil tablets are indicated to take care of excessive sleepiness and never as cure for the underlying obstruction. If ongoing positive airway stress (CPAP) may be the cure of option for a client, a maximal hard work to treat with CPAP for an adequate length of time really should be manufactured before initiating And through cure with modafinil tablets for extreme sleepiness. click here 2 DOSAGE AND ADMINISTRATION
primidone will lessen the extent or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
This medication comes with an extra patient reality sheet referred to as a Medication Guidebook. Study it with care. Browse it once more every time modafinil is refilled. When you have any questions about modafinil, please speak with the health practitioner, pharmacist, or other overall health care provider.
Pregnancy. It's not at all identified if or how modafinil could impact pregnancy or harm an unborn newborn. Explain to your healthcare service provider For anyone who is or program to become Expecting. Your healthcare provider will recommend you if you ought to take modafinil if you are pregnant or trying to get pregnant.
More than fifty% of amphetamine team noted signs and symptoms of excitation, contentment, and dry mouth. Modafinil team was not substantially various from placebo group in adverse outcomes.
Stiripentol is a CYP3A4 inhibitor and inducer. Check CYP3A4 substrates coadministered with stiripentol for enhanced or lessened effects. CYP3A4 substrates might demand dosage adjustment.
Steer clear of or substitute another drug for these remedies when doable. Consider for loss of therapeutic result if medication have to be coadministered.
Change perform disorder, a ailment (primarily in individuals Doing the job evening, early early morning, or rotating shifts) involving difficulties sleeping when you have to and/or Extraordinary sleepiness when you must be awake